China Accepts Junshi Biosciences’ COVID-19 Drug Application

Junshi Biosciences, a Chinese biopharmaceutical firm, introduced on January 18 that the nation’s medical merchandise authorities had accepted a brand new drug software for Deuremidevir Hydrobromide Tablets (venture code: JT001/VV116) for the remedy of COVID-19. This represents one other home COVID-19 oral medication that has been accepted for launch not too long ago after Simcere Pharmaceutical’s “Xiannuoxin.”

Junshi Biosciences was established in December 2012, and has greater than 50 merchandise underneath analysis, protecting 5 main remedy fields, together with malignant tumors, autoimmune system ailments, continual metabolic ailments, nervous system ailments and infectious ailments.

VV116 was collectively developed by Junshi Biosciences, the Shanghai Institute of Materia Medica of Chinese Academy of Sciences, Suzhou Wangshan Wangshui Biomedical Co., Ltd. Junshi Biosciences and Wangshan Wangshui collectively undertake the medical improvement and industrialization of the drug in 5 Central Asian nations, Russia, North Africa and the Middle East.

Before the home itemizing software of VV116 was accepted, the drug was launched in Uzbekistan for the remedy of reasonable or extreme COVID-19 sufferers.

Junshi Biosciences stated that VV116 can non-covalently bind to the lively middle of novel coronavirus RNA polymerase within the type of triphosphate, which instantly inhibits the exercise of virus RNA polymerase and blocks the replication of offspring virus, thus attaining an antiviral impact. The firm additionally stated that preclinical research confirmed that VV116 confirmed important antiviral impact on novel coronavirus, and had no genotoxicity.

On December 29, 2022, the New England Journal of Medicine revealed the outcomes of a Phase III medical examine of this drug in contrast with Pfizer’s Paxlovid, displaying that VV116 had a shorter medical restoration time and fewer security considerations.

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On January 5, the identical journal revealed an unique interview, revealing that Pfizer’s Paxlovid has limitations in precise use, and the mixed ritonavir can intervene with the metabolism of many medication, whereas in contrast with remdesivir, VV116 can break the limitation of its dosage kind and is extra handy to make use of.

Up to now, three COVID-19 oral medicines – Pfizer’s Paxlovid, Merck’s Molnupiravir and Genuine Biotech’s Azvudine – have been authorized in China, with costs of 1,890 yuan ($279)/field, 1,500 yuan/bottle and 270 yuan/field respectively, and are quickly included in medical insurance coverage reimbursement schemes till March 31 this 12 months.

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